Three days of traveling, walking, learning, seeing friends and family and more alcohol than the zero i normally drink had me pretty wiped out by Monday morning and I actually slept too late to get a run in before packing and getting to another early morning lecture on time.
When it first started being used for opiate addiction (it is better than Methadone in a few respects) we were told to stop it before surgery or our opiates would not work at all but except at highest doses there are usually still some receptors available.
